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KMID : 0357920130470050466
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Korean Journal of Pathology
2013 Volume.47 No. 5 p.466 ~ p.471
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Fine Needle Aspiration Cytology of Parathyroid Lesions
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Heo Il-Yeong
Park Sun-Hoo
Jung Chang-Won
Koh Jae-Soo
Lee Seung-Sook
Seol Hye-Sil
Choi Hee-Seung
Cho Soo-Youn
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Abstract
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Background: There has been an increase in the use of fine needle aspiration cytology (FNAC) for the diagnosis of parathyroid lesions (PLs). Differentiation between a thyroid lesion and a PL is not easy because of their similar features. We reviewed parathyroid aspirates in our institution and aimed to uncover trends in diagnostic criteria. Methods: We selected 25 parathyroid aspirates (from 6 men and 19 women) confirmed surgically or immunohistochemically from 2006 to 2011. Results: Major architectural findings of PLs include scattered naked nuclei, loose clusters, a papillary pattern with a fibrovascular core, tight clusters, and a follicular pattern. These architectures were commonly admixed with one another. Cytological features included anisokaryosis, stippled chromatin, a well-defined cell border, and oxyphilic cytoplasm. Eighteen of the 25 patients were diagnosed with PL using FNAC. Seven patients had been misdiagnosed with atypical cells (n=2), benign follicular cells (n=2), adenomatous goiter (n=2) and metastatic carcinoma (n=1) in FNAC. Using clinicoradiologic data, the sensitivity of the cytological diagnosis was 86.7%. The cytological sensitivity decreased to 50% without this information. Conclusions: FNAC of PL is easily confused with thyroid lesions. A combination of cytological parameters and clinical data will be required to improve the diagnostic sensitivity of PLs.
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KEYWORD
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Parathyroid lesions, Biopsy, fine-needle, Cytology
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